the Role of Platelet-Rich Fibrin in Periodontal and Peri-Implant Healing: Mechanisms of Growth Factor Release and Scaffold Properties with Clinical Implications

Abstract

Platelet-rich fibrin (PRF) has shown great potential in periodontal and peri-implant tissues as a biomaterial, for its favourable characteristics of growth factor delivery and bio-scaffold. This review traces the concept of PRF in an assessment of its potential for tissue regeneration, its ability to deliver pertinent growth factors including platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF- β) and vascular endothelial growth factor (VEGF). These factors help in the process of stimulating cell division, development of new blood vessels and eventually collagen synthesis. Besides, PRF’s fibrin framework allows cell mobility and tissue incorporation, which also favoured the healing events. This review highlights the fact that PRF enhances clinical efficacy in periodontal and peri-implant therapy concerning tissue regeneration and decrease in inflammation.