Study the Effect of Drug “Statin” On Hepatic Lipid Metabolism Using System Biology Approach

Abstract

In developing countries, the cardiovascular diseases (CVD) are the major cause for death. Statin is the preferred medication for the treatment of cardiovascular diseases. The main objective of our research is to simulate the hepatic lipid metabolism (existing model) with drug of specific concentration and identify the effect on other metabolic molecules of the model and identify that how drug molecule associated with diseases like atherosclerosis and dyslipidemia in hepatic lipid metabolism. In our research, we are using mathematical modeling and computer simulation to study the effect of the drug “Statin” on lipid metabolism. Our research is very useful to investigate that how drug affects or reduce the LDL level.