Synthetic and Antibacterial Profiling of 4-Methyl-N-(2-Morpholinoethyl) Benzene Sulfonamide

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Sajid Mahmood, Amimah Ashraf, Muhammad Waheed Rasheed, Amina Ashgar, Tamim Dari, Murat Cancan


Morpholine sulphonamide (4-Methyl-N-(2-morpholinoethyl) benzene sulfonamide) and their derivatives were synthesized. 2-morpholinoethylamine reacted with 4-Methyl benzene sulphonyl chloride in the presence of 10% Na2CO3 to form the product 4-Methyl-N-(2-morpholinoethyl) benzene sulfonamide. Derivatives of Morpholine sulfonamides was formed by reaction of above formed product using different organic halides. LiH taken as base and DMF was used as solvent. Biological activity of synthesized compound examined by using different strains of bacteria including Streptococcus faecalis, Escherichia Coli, S. typhi, Staphylococcus aureus, Pseudomonas aeruginosa. Some compounds exhibit antibacterial activity. The compounds 3Ac and 3Ad showed outstanding antibacterial activity against Pseudomonas aeruginosa (-) while compound 3Ab showed anti-E. coli activities. Synthesized compounds characterization was done by 1H-NMR, Mass spectrometry & IR spectroscopy.

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